With the suitable modifications in the structure 1,4-dihydropyrazol-5-one a five membered heterocycle has been found with enormous biological activities. The present review is an attempt made to direct the attention of the researchers towards the 1,4-dihydropyrazol-5-one moity for the development of newer chemical entities which will be quite useful in the treatment of various life threatening diseases and disorders. Along with the development in the various methods used for synthesis of 1,4-dihydropyrazol-5-one with profound biological activities one can proceed with newer area of Medicinal chemistry.
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